激素节律障碍是潜在的贡献者,以后手术的认知功能障碍的下垂体瘤手术
Neuroendocrinology
|March 13, 2026
概括
下垂体手术后的术后认知功能障碍 (POCD) 与激素缺乏有关. 解决荷尔蒙失衡和节律可能会改善这些患者的认知结果.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 外科手术的结果
背景情况:
- 手术后认知功能障碍 (POCD) 是手术后经常出现的并发症.
- 驱动POCD的精确机制仍然不完全理解.
- 假设在下垂体手术后的荷尔蒙变化有助于POCD的发病.
研究的目的:
- 为了研究手术后荷尔蒙状态和脑功能之间的关系,在患有下垂体手术的患者中.
- 评估POCD与激素替代疗法相关的流行和进展情况.
主要方法:
- 一项为期12个月的随访研究包括103名患有垂体腺瘤的患者.
- 根据术后的荷尔蒙补充剂,患者被分组为:稳定,充足或不足.
- 认知功能使用迷你心理状态检查 (MMSE) 和蒙特利尔认知评估 (MoCA) 进行评估.
主要成果:
- 从手术后6个月开始,足够和不足的荷尔蒙组的认知分数 (MoCA和MMSE) 降低了.
- 与稳定组相比,充足和不足组在6个月和12个月后表现出认知得分下降.
- 轻度认知障碍和痴呆症的发病率在3个月内显著增加,在足够群体中进展较慢.
结论:
- 在患有下垂体瘤手术后的患者中,POCD非常普遍.
- 手术后的荷尔蒙缺乏症,特别是涉及ACTH和葡萄皮质激素,显著影响POCD的进展.
- 荷尔蒙节律的障碍被确定为POCD的新型潜在贡献者,这表明需要进行时代生物学激素替代治疗.
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