使用临床和手术因素,针对唾液状细胞癌的基于SEER的生存名录
Xuying Zheng1, Junbing He2, Yufu He2
1The Department of Stomatology, Jieyang People's Hospital (Jieyang Affiliated Hospital of Sun Yat-sen University), Guangdong, China.
Medicine
|March 13, 2026
概括
一个新的诺莫格拉姆模型准确地预测了细胞癌 (AcCC) 患者的整体存活率. 这个工具可以帮助临床医生个性化治疗,并改善AcCC的结果.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 阴细胞癌 (AcCC) 具有显著的复发,转移和死亡风险.
- 在AcCC中,总生存期 (OS) 的预测模型对于临床决策至关重要.
研究的目的:
- 为了确定在AcCC患者中OS的独立预后因素.
- 在AcCC中开发和验证一个用于预测OS的nomogram.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 计划和独立医院队列的数据.
- 使用单变量/多变量考克斯回归分析来确定预后因素.
- 使用校准曲线,ROC曲线和一致性索引验证了名ogram.
主要成果:
- 确定了年龄,性别,晚期T,N和M阶段以及手术类型作为OS的独立预后因素.
- 在训练组中,名图显示出强大的预测性能,一致性指数为0.824和AUC为0.864 (3年) 和0.829 (5年).
- 内部和外部验证证实了诺莫格拉姆的准确预后预测和预测和观察到的生存时间之间的绝佳一致性.
结论:
- 结合临床特征和手术类型的新型名图,可以准确预测AcCC患者的3年和5年的生存期.
- 这种经过验证的工具提供了个性化的预后信息,帮助临床医生优化治疗并改善患者的治疗结果.
- 将其纳入临床实践可以提高AcCC的决策和患者管理.
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