炎症生物标志物在分化大动脉动脉瘤和剖析中的诊断和区分价值:一项回顾性比较研究
Hasan Büyükaslan1, Ezhar Ersöz2, Murat Ziya Bağiş2
1Department of Emergency Medicine, Faculty of Medicine, Harran University, Şanliurfa, Turkey.
Medicine
|March 13, 2026
概括
像中性粒细胞与淋巴细胞比率 (NLR) 这样的简单血液测试可以帮助快速诊断大动脉解剖 (AD) 和大动脉动脉瘤 (AA). 这些炎症标志物与临床因素相结合,在成像延迟时改善了早期诊断.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 紧急医疗 紧急医疗
背景情况:
- 急性大动脉综合征,包括大动脉解剖 (AD) 和大动脉动脉瘤 (AA),是危及生命的疾病,死亡率高.
- 快速和准确的诊断对于及时干预和改善患者结果至关重要.
- 虽然成像是黄金标准,但在紧急情况下需要可访问的辅助诊断工具.
研究的目的:
- 评估各种血液学指数和炎症生物标志物的诊断和区分价值,以区分AD和AA与健康对照和彼此.
- 评估血液学指数与临床风险因素的综合诊断性能.
主要方法:
- 追溯性比较研究涉及576名参与者 (213名AD,178名AA,185名对照).
- 对人口统计,临床和实验室数据的分析,包括中性粒细胞与淋巴细胞的比率 (NLR),血小板与中性粒细胞的比率以及纤维素与d-二次体的比率.
- 采用了接收器操作特征 (ROC) 曲线分析和多变量逻辑回归模型.
主要成果:
- 与对照组相比,AD和AA患者的炎症指数显著增加 (P < .001).
- 在区分阿尔茨海默病与对照病的过程中,NLR显示出高准确度 (AUC=0.933),而NLR和血小板与中性粒细胞的比率则预测了AA与对照病的情况.
- 纤维素与d-二分体的比率在区分AD与AA方面表现最好 (AUC=0.898).
- 结合临床因素和血液学指数的组合模型,在所有比较中实现了优异的歧视.
结论:
- 简单的血液学比率,特别是NLR和纤维素与d-二次数比率,为急性大动脉综合征提供了显著的诊断和区分价值.
- 将这些生物标志物与临床风险因素相结合,可以提高早期分拣和差异诊断,特别是当高级成像无法或延迟时.
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