确定癌症综合征患者的预后:一个回顾性单中心队列研究
Merijn C F Mulders1, Celine F Maas1, Richard A Feelders1
11Section of Endocrinology, Department of Internal Medicine, ENETS Center of Excellence, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Journal of the National Comprehensive Cancer Network : JNCCN
|March 13, 2026
概括
患有癌症综合征 (CS) 的患者主要死于神经内分泌瘤 (NET). 关键的死亡率预测因素包括年龄,瘤等级,肺部起源和染色蛋白A水平,突出显示需要更好的CS治疗方法.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 癌症综合征 (CS) 是与神经内分泌瘤 (NETs) 相关的最常见的激素综合征,导致生存率降低.
- 在CS患者中,NET相关死亡的具体贡献仍然不清楚.
- 了解死亡原因对于改善患者的治疗结果至关重要.
研究的目的:
- 评估CS患者的整体存活期 (OS).
- 确定影响CS生存的预后因素.
- 确定CS患者的主要死亡原因.
主要方法:
- 在1995年至2021年期间接受治疗的CS患者的回顾性分析.
- 卡普兰-梅尔曲线和存活率分析的日志等级测试.
- 考克斯的比例危险模型用于确定死亡率预测因素.
主要成果:
- 在CS患者中,90%以上的死亡是NET特异性的.
- 平均寿命为7.1年;5年和10年生存率分别为65.1%和34.1%.
- 死亡率的独立预测因素包括年龄,世卫组织2级瘤,血染色素A (CgA) 水平升高和初级肺 NET.
结论:
- 脑脊髓病患者有很高的可能性屈服于他们的NET.
- 年龄,瘤等级,初级肺 NET 和 CgA 水平是死亡率的重要独立预测因素.
- 迫切需要为CS开发先进的治疗策略.
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