杏仁体和轨道前皮层的内记录显示了面部情绪处理期间的时间反应和定向连接模式
Kaitlyn E Davis1, Adam M Goodman2, Melissa D Thye3
1Department of Neurology, University of Alabama at Birmingham, Heersink School of Medicine, Birmingham, AL, USA.
Epilepsy & behavior : E&B
|March 13, 2026
概括
这项研究揭示了杏仁体和轨道前皮层 (OFC) 如何使用内脑电图 (iEEG) 处理面部情绪. 研究结果显示,杏仁体的兴奋反应和泰达带连接对于前边缘电路中的情绪处理至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 精神病学是一个精神病学.
背景情况:
- 面部情绪处理对于社会功能至关重要,但在等神经精神疾病中受损.
- 杏仁体和轨道前皮层 (OFC) 是处理情绪的关键大脑区域,但它们的相互作用动态尚不清楚.
- 当前神经成像方法的局限性阻碍了研究这些电路中的快速神经相互作用.
研究的目的:
- 在隐性面部情绪处理过程中调查杏仁体和OFC之间的功能相互作用.
- 描述杏仁体-轨道前线电路内的高玛和达频段活动和连接性.
- 探索中情绪处理缺陷背后的神经机制.
主要方法:
- 利用内脑电图 (iEEG) 来直接记录来自杏仁体的神经活动,中间的OFC (mOFC) 和侧面的OFC (lOFC).
- 分析了来自25名耐药患者的数据,他们执行了隐式面部情绪处理任务.
- 检查了局部高马 (70-150 Hz) 响应和以太频段 (4-7 Hz) 的指导功能连接.
主要成果:
- 杏仁体对恐惧和快乐的面孔表现出快速激活,这表明基于兴奋而不是价值的反应.
- 中间和侧面的OFC分区域都对情感面孔表现出延迟的反应,活动与行为表现相关.
- 从杏仁体到mOFC之间显示出显著的自下而上的达频段连接,以及mOFC和lOFC之间的双向连接.
结论:
- 泰达波段连接支持低频通信,对于协调前边缘电路的情绪处理至关重要.
- 这些发现阐明了面部情绪处理的神经动态,并突出了症治疗干预的潜在目标.
- 这项研究提供了关于杏仁体和OFC在情绪调节中的时空相互作用的新见解.
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