在接受接受和承诺治疗的偶发性偏头痛妇女中,皮质醇唤醒反应
Myrella Paschali1, Carolyn Ann Bernstein2, Theodoros Paschalis3
1Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Journal of psychiatric research
|March 13, 2026
概括
皮质醇唤醒反应 (CAR) 可能预测在偶发性偏头痛患者的治疗成功. 基线CAR显示在接受和承诺治疗 (ACT) 后,与偏头痛相关的残疾减少相关的趋势.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病体医学是一种精神病体医学.
- 临床心理学 临床心理学
背景情况:
- 皮质醇唤醒反应 (CAR) 是下丘脑-垂体-上腺 (HPA) 轴功能的一个关键生物标志物.
- 在偏头痛患者中研究HPA轴功能是有限的,并产生不一致的结果.
- 这项研究探讨了接受和承诺治疗 (ACT) 的偏头痛患者与CAR和心理社会结果之间的联系.
研究的目的:
- 调查皮质醇唤醒反应 (CAR) 与情节性偏头痛患者的心理社会结果之间的关联.
- 检查CAR如何与头痛相关的残疾,抑郁,焦虑,疼痛灾难化,痛苦耐受性以及在ACT前后感知压力的关系.
- 确定CAR是否可以在偏头痛管理中作为治疗反应的预测指标.
主要方法:
- 32名发作性偏头痛患者接受了8个小组ACT会议.
- 唾液皮质醇在唤醒时被测量,在唤醒后15分钟和45分钟,以及干预前和后.
- 自我报告问卷评估了心理社会结果;计算了CAR,并使用多重线性回归分析了相关性.
主要成果:
- 醒来的皮质醇水平保持在正常范围内,并且干预后没有显著变化.
- 基线CAR与抑郁症有负相关性,并在ACT后显示趋势水平与偏头痛相关残疾减少的相关性.
- 治疗前后没有观察到CAR或唤醒皮质醇的显著变化.
结论:
- 皮质醇唤醒反应 (CAR) 显示出作为在偶发性偏头痛中治疗反应的生物标志物的潜力.
- 初步发现表明,CAR可能与ACT后偏头痛相关残疾的改善有关.
- 需要进行更大,更多样化的研究来验证这些初步发现,并扩大对偏头痛中CAR的理解.
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