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Updated: Mar 15, 2026

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
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高灵敏度MAM用于支持生物治疗开发过程中的早期活动

Silvia Millán-Martín1, Anna Mulligan2, Lisa Füssl1

  • 1Characterisation and Comparability Laboratory, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Co. Dublin, A94 X099, Ireland.

Journal of chromatography. A
|March 13, 2026
PubMed
概括

一种新的纳米流液体色谱-并联质谱 (LC-MS/MS) 多属性方法 (MAM) 提供了对生物治疗的敏感和强大的描述. 这种方法使早期生物工艺开发和质量控制应用成为可能.

关键词:
关键的质量属性是关键的质量属性.单克隆抗体是一种单克隆抗体.多属性方法多属性方法.没有一个NISTmAbAb.新峰值检测检测的新峰值检测类映射映射 类映射纳米流 LC-MS 的使用.

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