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对于非肌肉侵入性膀癌的静脉内疗法的进展

Yanfeng Tang¹, Ling Wang¹, Haoyang Liu¹

¹Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Critical reviews in oncology/hematology

|March 13, 2026

概括

由于Bacillus Calmette-Guérin (BCG) 短缺,非肌肉侵入性膀癌 (NMIBC) 治疗正在发展. 新的静脉内疗法在NMIBC患者中显示出复发和进展的前景.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

非肌肉侵入性膀癌 (NMIBC) 约占新诊断的膀癌的75%.
NMIBC与复发和进展的高风险有关.
输尿管内疗法是膀瘤转尿管切除后 (TURBT) 的标准管理方法.

研究的目的:

在各个风险群体中审查NMIBC目前的静脉内治疗策略.
突出新兴疗法,解决巴西路斯卡尔梅特-盖林 (BCG) 疗法的局限性.
讨论BCG耐药或BCG不响应的NMIBC的新方法.

主要方法:

对NMIBC目前的静脉内化学疗法和免疫疗法方案的审查.
分析新兴的静脉注射剂和新型药物输送系统.
探索基因疗法,性病毒疗法和其他向治疗方法.

主要成果:

对于低风险的NMIBC,TURBT化学疗法后立即灌注可以减少复发.
中级风险的NMIBC可能会从化疗或BCG中受益,化疗作为一个有前途的选择.
高/非常高风险的NMIBC标准是3年BCG,但由于缺乏,需要采用优化的BCG或顺序的gemcitabine/docetaxel灌注等替代方案.

结论:

由于BCG短缺和治疗失败,因此需要替代NMIBC静脉注射策略.
优化的BCG疗法和连续的静脉内化学疗法显示出潜在的治疗潜力.
包括基因疗法,瘤病毒和向剂在内的新型疗法为BCG失败的NMIBC提供了有前途的途径.

关键词:

没有对BCG反应的BCG不响应.免疫检查点抑制剂免疫检查点抑制剂静脉内化学疗法静脉内化学疗法膀癌是非肌肉侵入性的膀癌.新的静脉内治疗方法

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