内抗血管内皮生长因子注射对白内障发展的影响
Jaehwan Choi1, Eunjung Choi2, Se Woong Kang3
1Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea.
Ophthalmology
|March 13, 2026
概括
长期的静脉注射抗血管内皮生长因子 (抗VEGF) 注射显著增加了白内障手术的风险. 接受这些治疗的患者的10年累计发病率为40.7%,而未接受治疗的患者的7.2%.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 白内障研究 白内障研究
背景情况:
- 静脉内抗血管内皮生长因子 (抗VEGF) 疗法是各种视网膜疾病的常见治疗方法.
- 反复注射抗VEGF对眼睛结构,特别是眼镜的长期影响需要彻底调查.
研究的目的:
- 评估单边静脉内抗VEGF注射和随后需要白内障手术之间的关联.
- 与未经治疗的眼睛相比,用抗VEGF治疗的眼睛患白内障需要手术的风险要定量.
主要方法:
- 对于那些接受了至少12次单方面抗VEGF注射的发光透镜患者,进行了电子病历的回顾性分析.
- 卡普兰-梅尔生存分析被用来比较注射和未经治疗的眼睛之间白内障手术的累积发病率.
- 镜片的不透明度等级和视敏度变化在手术时被分析.
主要成果:
- 在74个月的中位随访期内,白内障手术的10年累计发病率在注射眼睛中为40.7%,而同眼睛的7.2%.
- 内抗VEGF治疗与白内障手术的风险增加了8.17倍 (HR,8.174;95% CI,5.767-11.586).
- 在注射眼睛中观察到显著更高的核,皮层和后部亚囊透镜不透明度,后部亚囊不透明度显示出最大的差异.
结论:
- 长期的内抗VEGF治疗与增加白内障发展风险显著相关,需要手术干预.
- 这些发现突显了持续抗VEGF治疗的潜在并发症,需要仔细监测患者并考虑透镜健康状况.
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