婴儿IgE甲基化得分和儿童喘息和喘;一个多队列研究
Anat Yaskolka Meir1, Yijun Li1, Zhaozhong Zhu2
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
The Journal of allergy and clinical immunology
|March 13, 2026
概括
早期生命表观遗传编程,通过表观遗传总IgE (DNAm-IgE) 评分来衡量,预测儿童的呼吸问题,如超出标准IgE水平的喘息. 这一分数提供了关于喘发展的见解.
科学领域:
- 儿科过敏和免疫学
- 表观遗传学和基因与环境的相互作用
- 呼吸系统医学 呼吸系统医学
背景情况:
- 早期的表观遗传编程影响了与喘和喘相关的基因环境相互作用.
- 多CpG甲基化得分可以捕捉高免疫球蛋白E (IgE) 的表观遗传倾向,超过观察到的IgE水平.
研究的目的:
- 建立和评估表观遗传总IgE (DNAm-IgE) 评分对儿童呼吸系统发病率的残留影响.
- 调查表观遗传标记对呼吸系统健康结果的预测价值.
主要方法:
- 利用了来自三个队列 (MARC-35,MARC-43,BBC) 的数据,以及来自婴儿/带血的DNA甲基化数据.
- 使用Illumina EPIC阵列数据开发并验证了表观遗传总IgE (DNAm-IgE) 评分.
- 评估的总IgE,在3岁时出现复发性喘息,在6岁时出现喘.
主要成果:
- DNAm-IgE评分在MARC-35 (R=0.502与总IgE) 中进行训练和评估,并在MARC-43 (R=0.309) 和BBC (R=0.132) 中得到验证.
- 在元分析中,DNAm-IgE得分残留与复发性喘息相关 (OR=1.33),而总IgE与喘相关 (OR=1.45).
- 模型根据性别,种族/种族和出生体重进行了调整.
结论:
- 与总IgE相关的早期表观遗传模式可能会独立于测量IgE,导致以后的呼吸道发病率.
- DNAm-IgE评分及其残留物是呼吸系统健康研究的有希望的探索工具.
- 对于DNAm-IgE评分,需要进一步的验证和机制研究.
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