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Updated: Jul 21, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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母体颗粒细胞殖民地刺激因子改变了子孙的突触成熟和社会行为

Hinako Kirikae1, Karina Kimura1, Jinghang Fu1

  • 1Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Sendai, Japan.

Brain, behavior, and immunity
|March 13, 2026
PubMed
概括

颗粒细胞殖民地刺激因子 (G-CSF) 可能会调解孕产妇免疫激活对胎儿大脑发育的影响. 这种造血生长因子改变了后代的突触成熟和社会行为,这表明它在神经发育障碍中发挥了作用.

关键词:
自闭症谱系障碍 (ASD) 是一种细胞因子细胞因子颗粒细胞殖民地刺激因子 (G-CSF)孕产妇免疫激活 (MIA) 的原因微质细胞中的微质细胞神经发育障碍 神经发育障碍前额叶皮层前额叶皮层.产前环境 产前环境社会行为社会行为.突触发展突触的发展.

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