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Karen Gabriela Favaro de Souza¹, Gabrielle Chalupa Faria¹, Débora Hipólito Quadreli¹

¹Department of General Biology, Center for Biological Sciences, State University of Londrina - UEL, Londrina, Paraná, Brazil; Department of Immunology, Parasitology and General Pathology, Center for Biological Sciences, State University of Londrina - UEL, Londrina, Paraná, Brazil.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|March 13, 2026

概括

低剂量N-Nitrosodimethylamine (NDMA) 暴露导致大鼠的直接和代际前列腺毒性. 这种环境污染物影响着前列腺健康,突出了公众健康的担忧.

科学领域:

环境毒理学环境毒理学
生殖毒理学生殖毒理学
表观遗传学和健康和疾病的发育起源.

背景情况:

尼二甲胺 (NDMA) 是一种在水和食品中发现的环境污染物,由于其持久性和致癌性,它存在毒理和公共卫生风险.
健康和疾病的父性起源 (POHaD) 框架调查了父母暴露如何影响子女跨代健康.

研究的目的:

在POHaD框架内,评估低剂量NDMA暴露对两代 (F0和F1) 的雄性Wistar大鼠前列腺的影响.
评估NDMA对前列腺组织学,原蛋白组成,炎症和基因表达的直接和代际影响.

主要方法:

雄性Wistar大鼠 (F0) 从出生后的第60天到第104天通过 gavage暴露于低剂量的NDMA (7.2 ng/kg/day).
用立体学,原分析和RT-qPCR对基因表达 (雌激素受体,TNF-α,IL-6) 进行前列腺组织分析.
后代 (F1) 在出生后的第70天 (父亲暴露) 和出生后的第120天 (直接暴露) 被评估.

主要成果:

暴露于NDMA导致F0男性前列腺体重增加,F0和F1 (PND120) 前列腺上皮质扩张/光线缩小.
在整个暴露组和几代人之间观察到前列腺间歇区域和 I 和 III 类型的原蛋白的显著变化.
在暴露的老鼠中,发现了炎症透,巨细胞脱粒化,改变的雄激素受体表达,以及TNF-α和IL-6水平的变化.

结论:

低剂量的NDMA暴露会在雄性大鼠中诱导直接和代际前列腺毒性.
这些发现支持POHaD概念,表明父亲暴露于环境污染物可能会影响后代的前列腺健康.
NDMA对前列腺健康构成重大风险,需要对其长期影响和公共卫生影响进行进一步调查.

关键词:

环境污染物的环境污染物.在NDMA中,NDMA是最重要的.已经可以了.前列腺前列腺前列腺有毒性有毒性

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