一种快速的方法来预测中性共同晶体在水性介质中的溶解度
Asbjørn Jaensch Rasmussen1, Matteo Guidetti1, Rolf Hilfiker2
1Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
概括
这项研究提出了一种新的热力学方法来预测共同晶体溶解度,减少溶解性差的药物的实验力度. 该方法准确估计溶解度,有助于早期药物开发和固体形式的选择.
科学领域:
- 制药科学 制药科学
- 物理化学 物理化学
- 材料科学 材料科学 材料科学
背景情况:
- 共同晶体作为改善难溶药物 (API) 物理化学性质的配方,正在引起人们的兴趣.
- 同一个API的不同联合晶体可以表现出不同的溶解度,影响溶解概况和药物疗效.
- 确定共同晶体溶解度的传统方法,如测量度在eutectic点,是耗时和材料密集的.
研究的目的:
- 引入一种新的,简化的热力学方法,用于预测在各种介质 (包括生理条件) 中的共晶溶性.
- 通过减少实验工作量和时间来克服传统实验方法的局限性.
- 为了促进更快,更准确的溶解度估计在药物开发的早期阶段和固体形式查.
主要方法:
- 拟议的方法通过在合成过程中测量API和辅助前体度来估计溶解性产物 (Ksp).
- 它还利用了API和辅助器在合成溶剂和目标介质中的个体溶解度.
- 该方法使用卡巴马西平-胺和西利尼迪平-p-toluenesulfonamide中性共晶系统进行了验证.
主要成果:
- 预测的共同晶体溶解度与实验中欧特克点测量结果非常相匹配.
- 这种方法即使在共同晶体溶解度不同两个数量级时也表现出有效性.
- 这种方法最大限度地减少了实验工作,因为单个组件可溶性数据可以重复使用.
结论:
- 新的热力学方法提供了快速且相当准确的共晶溶解度估计.
- 这种方法适用于药物开发的早期阶段和固体形式的选择,特别是1: 1 中性共晶体.
- 预测模型通过减少实验复杂性和资源需求,提供了显著的优势.
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