单一的第一食品对婴儿肠道微生物群的影响:随机对照试验
Lynn E Ferro1, Kyle Bittinger2, Sabrina P Trudo3
1Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE, USA.
The Journal of nutrition
|March 13, 2026
概括
引入多样化的第一补充食品 (CFs) 影响婴儿肠道微生物组的发展. 虽然牛肉提供营养,但它可能会减少微生物多样性,这表明需要与水果和蔬菜一起进行平衡的引入.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 婴儿肠道微生物组对于免疫功能,炎症和新陈代谢至关重要.
- 微生物组的可塑性随着年龄的增长而降低,这凸显了早期饮食暴露的重要性.
- 第一补充食品 (CF) 显著影响婴儿肠道微生物组的发育.
研究的目的:
- 调查不同初级补充食品 (CF) 对婴儿肠道微生物群的影响.
- 开展一项试点随机对照试验,评估CF对微生物多样性和组成的影响.
- 为了比较麦谷物,牛肉,胡卜和果作为初始CFs的影响.
主要方法:
- 一项试点随机对照试验,涉及43名纯母乳养的婴儿.
- 婴儿被分配给四种CF之一 (麦粉,牛肉,胡卜,) 一周,然后是麦粉.
- 每天收集便样本,并使用全长16S rRNA基因安普利康测序进行分析.
主要成果:
- 与第一阶段牛肉相比,麦谷物增加了观察到的安普利康序列变异 (ASV).
- 梅子引入导致特定细菌 (Bacteroides ovatus,Klebsiella pneumoniae) 的增加,而麦粉增加了Enterococcus spp. 相对于牛肉来说.
- 在第二阶段,在牛肉或肉后的麦谷物增强了微生物多样性 (Shannon和Faith的PD).
结论:
- 牛肉提供必要的矿物质,但与其他CF相比,可能导致肠道微生物群的差异较小.
- 水果和蔬菜的多样性与谷物相似,这表明可能会有均衡的引入.
- 未来的研究应该探索将肉类与水果/蔬菜结合起来,以及对微生物种类和宿主通路的详细影响.
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