一小时血葡萄糖和早期心脏代谢风险在多囊性卵巢综合征的正常血糖妇女:一个回顾性跨部分研究
Linlin Jiang1,2, Yifan Qian1, Ping Pan1,2
1Department of Obstetrics and Gynecology, Reproductive Medicine Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
概括
在患有多囊性卵巢综合征 (PCOS) 的女性中,1小时血葡萄糖 (1hPG) 的升高与心脏代谢风险因素的增加有关. 这一发现表明,1hPG可以帮助识别需要更密切监测心血管健康的女性.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 评估心血管风险评估
背景情况:
- 多囊卵巢综合征 (PCOS) 与心脏代谢风险因素有关.
- 患有PCOS的正常血糖妇女可能仍然存在心脏代谢风险升高.
- 早期识别心脏代谢风险因素 (CMRFs) 对PCOS管理至关重要.
研究的目的:
- 在患有PCOS的正常血糖女性中,研究1小时血葡萄糖 (1hPG) 和CMRF升高之间的关联.
- 确定1hPG是否可以作为该人群中心脏代谢风险的早期指标.
主要方法:
- 对1152名患有PCOS的生育年龄妇女进行了回顾性横截面研究.
- 基于1hPG水平的参与者的分层 (正常与升高≥8.6 mmol/L).
- 评估CMRFs包括超重,中心肥胖,高血压和脂质不良;后勤回归分析.
主要成果:
- 在22.3%的女性中观察到高1hPG,并与超重,中心肥胖和脂质失调的更高患病率有关.
- 在高1hPG和≥1CMRF (aOR 1.91) 的存在之间发现了显著的关联.
- 在年龄调整后,这种关联在超重,中心肥胖和脂质不良症方面持续存在.
结论:
- 升高的1hPG与PCOS的正常血糖女性心脏代谢概况不太有利有关.
- 在口服葡萄糖耐受性测试期间,1hPG可能是早期心脏代谢风险丰富的有用辅助标志物.
- 需要进一步的前性研究来验证这些发现.
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