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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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网站-1蛋白酶介导的GPC处理对于LCMV克隆13的持久性是必要的

Ruifeng Zhou1, Haydar Witwit1, Tingting Ai1

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

Npj viruses
|March 14, 2026
PubMed
概括

哺乳类病毒独特地使用Site-1蛋白酶 (S1P) 进行糖蛋白加工. 针对S1P提供了一种针对这些病毒的新型抗病毒策略,影响它们的健康和免疫规避.

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Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...