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Updated: Mar 15, 2026

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
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受损的凝聚力负荷会通过Polycomb驱动的染色质重新连接和循环崩来破坏胰腺分化

Longtao Yu1,2, Yayu Liu1,2, Jie Zhang1,2

  • 1State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.

Communications biology
|March 14, 2026
PubMed
概括

凝聚蛋白加载器NIPBL的破坏破坏了关键的增强剂-促进剂相互作用和CTCF循环,导致细胞分化过程中的转录失调. 这突显了凝聚力加载.

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