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Updated: Mar 15, 2026

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在多囊脏的代谢重编程过程中,GLIS3对PKM2的表达和功能进行调节

Justin B Collier1, Hong Soon Kang1, Sara A Grimm2

  • 1Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Experimental & molecular medicine
|March 14, 2026
PubMed
概括

类似GLI3 (GLIS3) 缺乏症通过促进有氧糖解导致多囊性病. GLIS3调节糖溶性基因,包括PKM2,这是囊形成的关键驱动因素. 抑制PKM2可以减少GLIS3缺陷脏中的囊生长.

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