术前维生素D作为MRONJ的预测剂:一个追溯的多变量分析
Raluca Maracineanu1, Serban Talpos-Niculescu2, Marilena Dinuți3
1Doctoral School, "Victor Babeș" University of Medicine and Pharmacy, 300062 Timisoara, Romania.
Journal of clinical medicine
|March 14, 2026
概括
手术前的维生素D缺乏是牙拔牙的癌症患者中与药物相关的骨缩 (MRONJ) 的关键预测因子. 低维生素D水平显著增加了MRONJ的风险,有助于更好的预防策略.
科学领域:
- 在瘤学瘤学.
- 在口腔外科手术.
- 内分泌学 在内分泌学.
背景情况:
- 与药物相关的骨 (MRONJ) 是抗吸收治疗的癌症患者的一种严重并发症.
- 评估MRONJ风险因素,特别是在侵入性牙科手术之前,仍然是一个临床挑战.
研究的目的:
- 确定可靠的临床和代谢因素,预测在接受牙科拔牙的癌症患者中MRONJ风险.
- 评估手术前维生素D和β-CTX水平与红斑发育的相关性.
主要方法:
- 对61名癌症患者进行牙的回顾性观察性研究.
- 测量了手术前的血清25-基维生素D和β-C终端端别交叉链接 (β-CTx) 水平.
- 利用比较测试,多变量逻辑回归和ROC曲线分析用于预测建模.
主要成果:
- 红斑发生在29.5%的患者中.
- 手术前维生素D水平较低是MRONJ的独立预测因子 (OR=8.74,p=0.005).
- 提取部位也是一个显著的风险因素 (OR=7.94,p=0.007);β-CTX水平和其他临床因素不是显著的预测因素.
结论:
- 手术前的维生素D缺乏是抗吸收药物治疗癌症患者牙提取后MRONJ的重要独立预测因子.
- 将像维生素D这样的生物标志物与临床数据相结合,可以提高MRONJ风险评估.
- 改进的风险评估可以指导对MRONJ的更有效的手术前预防策略.
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