在血液动力学稳定患者的高压氧气治疗期间,生命体征和心电图发现的特定阶段变化:一项前性观察性研究
Seon Tae Kim1, Jeong Mi Lee2, Jeong Woo Choi1
1Department of Emergency Medicine, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea.
高压氧疗法 (HBOT) 导致可预测的生理变化,包括心率下降和短暂的心电图变化,特别是在减压期间. 在稳定的患者中,这种治疗耐受性良好,治疗后血压上升.
科学领域:
- 身体生理学 身体生理学
- 心脏病学 心脏病学
- 高压医学的高压医学.
背景情况:
- 在高压氧气疗法 (HBOT) 期间的生理反应尚不清楚,特别是在接受维持治疗的非紧急患者中.
- 在个别的HBOT疗程中监测生理变化对于临床管理至关重要.
研究的目的:
- 评估非急性患者在HBOT不同阶段的生理和心电图 (ECG) 变化.
- 评估接受HBOT的患者经历的临床症状.
主要方法:
- 一项前性观察性研究,涉及50名血液动力学稳定,非出现性HBOT患者.
- 在压缩前,压缩,维护,解压和治疗后阶段监测生命体征和心电图发现.
- 使用对生命体征的线性混合模型和对心电图异常的通用线性混合模型进行分析.
主要成果:
- 在HBOT阶段心率和呼吸率显著下降;在减压和治疗后,血压升高.
- 过渡性心电图异常发生在10%的患者中,主要发生在压缩和维护过程中;在压缩后的一例超心室性心动减压后自发消失.
- 氧和保持正常;没有显著的氧毒性或严重的不良事件被观察到.
结论:
- 高血压治疗诱导可预测的,短暂的生理变化,并且在稳定,非突发性患者中耐受良好.
- 血压升高在减压和治疗后最为明显,而在压缩/维护期间,心电图异常更为常见.
- 这些发现为特定阶段的HBOT生理反应提供了基础数据,并指导了对高风险人群的未来研究.
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