慢性低度炎症:COVID-19和新发性心房之间可能存在联系
Ciprian Ilie Roșca1, Daniel Florin Lighezan1, Daniel-Dumitru Nișulescu2
1Department V, Internal Medicine I-Discipline of Medical Semiology I, Center of Advanced Research in Cardiology and Hemostasology, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timișoara, Romania.
Journal of clinical medicine
|March 14, 2026
概括
后COVID患者表现出持续的炎症和内皮功能障碍,与心房动 (AF) 风险增加有关. 在基线时较高的炎症标志物和较低的口炎预测一年后更大的AF负担.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 持续性炎症和内皮功能障碍与COVID后的心血管问题有关,包括心房动 (AF).
- 了解这些机制对于在SARS-CoV-2感染后管理长期心血管后果至关重要.
研究的目的:
- 为了比较后COVID患者和对照者之间的炎症/原血栓生物标志物和内皮功能.
- 为了研究基线炎症/内皮功能障碍和COVID后12个月的AF负担之间的关系.
主要方法:
- 对198名门诊患者进行的回顾性观察研究 (99名COVID后,99名对照).
- 基线评估包括临床数据,炎症标志物 (ESR,CRP,纤维素,D-二次体),流媒扩张 (FMD) 和24小时霍尔特心电图.
- 12个月后的后续霍尔特心电图;对中性粒细胞与淋巴细胞比率 (NLR) 四分位数的分析.
主要成果:
- 后COVID患者的炎症标志物 (ESR,CRP,纤维素原,D-二次体) 升高,与对照组相比, FMD明显降低.
- 在COVID后的患者中,口病与炎症标志物相反相关 (ESR最强).
- 在12个月后的COVID后患者中,AF患病率在数值上更高,并且与更高的基线NLR和更低的口腔炎相关.
结论:
- 后COVID患者表现出持续的炎症-原血栓状况和内皮功能障碍.
- 一个炎症-内皮功能障碍轴似乎与COVID-19后一年的AF负担增加有关.
- 需要进一步的前性研究来证实这些发现,并探索管理策略.
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