针对局部性前列腺癌进行强度调节放射治疗的日本男性的生活质量:使用扩大前列腺指数复合 (EPIC) 患者报告的结果进行三年纵向评估
Norio Mitsuhashi1, Atsushi Motegi1, Hajime Ikeda1
1Department of Radiation Therapy, Hitachi, Ltd., Hitachinaka General Hospital, Hitachinaka City 312-0057, Japan.
Journal of clinical medicine
|March 14, 2026
概括
针对局部性前列腺癌的强度调节放射治疗 (IMRT) 对生活质量 (QOL) 的影响最小. 大多数尿路和肠道功能得分在三个月内恢复到基线,性功能仍然很低.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 局部性前列腺癌治疗显著影响患者的生活质量 (QOL).
- 强度调节放射治疗 (IMRT) 是一种常见的治疗方式.
- 雄激素剥夺疗法 (ADT) 通常与IMRT一起使用.
研究的目的:
- 评估局部性前列腺癌患者治疗IMRT,有或没有ADT的QOL的纵向变化.
- 用扩张前列腺指数复合物 (EPIC) 评估IMRT和ADT对各种QOL领域的影响.
主要方法:
- 长度分析EPIC总结和子域分数在8个时间点,最多在IMRT后3年.
- 在接受IMRT,ADT和不接受IMRT的患者之间比较QOL变化.
主要成果:
- 尿路和肠道分数在IMRT后早期出现过渡性下降,但在三个月后恢复到基线,不管ADT.
- 在整个研究期间,性功能得分始终保持在低水平.
- 随着时间的推移,荷尔蒙分数有所改善,荷尔蒙不适分数最初下降,然后在IMRT后3年增加.
结论:
- 通过减少不良事件,IMRT有效地减少局部前列腺癌患者的QOL恶化.
- 对尿路和肠道功能的影响通常是短暂的.
- 性功能对于接受前列腺癌IMRT的患者来说仍然是一个重大问题.
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