阴茎状细胞癌中偏性高热血病的机制,管理和预后:一个结构化的综述
Andrei Andreșanu1,2, Constantin Gîngu1,2, Mihaela Roxana Oliță3,4
1Department of Urology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Journal of clinical medicine
|March 14, 2026
概括
阴茎状细胞癌 (PSCC) 中的帕拉内瘤性高热血症是一种罕见的代谢紧急情况. 尽管有治疗,但存活率有限,这凸显了早期识别和多学科护理的必要性.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 偏膜性高血症是阴茎状细胞癌 (PSCC) 的罕见并发症.
- 关于其病理生理学,临床表现,治疗和结果的数据有限.
- 本综述系统地评估了PSCC中瘤诱导的高血症.
研究的目的:
- 综合审查PSCC中偏瘤性高血症的机制,临床特征,治疗方法和预后.
- 对这种罕见的瘤紧急情况综合现有证据.
主要方法:
- 从PubMed/MEDLINE和Scopus (2024年12月开始) 的文献进行系统的叙事审查.
- 纳入标准:经过实体病理学确认的PSCC,经过验证的高血症和副瘤病因.
- 数据提取的重点是瘤特征,高血症严重程度,机制,治疗和生存率.
主要成果:
- 确诊了12例病例 (1965年至2024年);中位数年龄为56岁,病情晚期的91.6%.
- 严重的高血症 (≥14毫克/分升) 在66.7% (中位数15.45毫克/分升).
- 机制包括PTHrP介导和骨转移;三个病例的机制尚未确定. 诊断后的中位生存时间为9周.
结论:
- 在PSCC中发生的副新生性高血症是一种罕见的代谢紧急情况,表明疾病已晚期.
- 积极的管理可以纠正水平,但提供有限的生存益处.
- 早期识别和多学科干预对于症状管理和生活质量至关重要.
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