在阻塞性睡眠呼吸暂停中,TyG-BMI和TG/HDL-C对代谢功能障碍相关的脂肪性肝病的预测价值:单中心回顾性队列分析
Furong Lv1,2, Tong Li1, Fei Zou3
1Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Journal of clinical medicine
|March 14, 2026
概括
甘油三指数与体重指数 (TyG-BMI) 和TG/HDL-C比率有效预测阻塞性睡眠呼吸暂停 (OSA) 患者的代谢功能障碍相关的脂肪性肝病 (MASLD). 将这些与ALT水平相结合,可以提高MASLD风险分层的预测准确性.
科学领域:
- 代谢健康 代谢健康
- 睡眠医学 睡眠医学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和阻塞性睡眠呼吸暂停 (OSA) 经常同时存在.
- 在OSA患者中确定MASLD的可靠预测因子对于早期干预至关重要.
研究的目的:
- 评估三糖-葡萄糖指数与体重指数 (TyG-BMI) 的预测值以及三糖与高密度脂蛋白胆固醇 (TG/HDL-C) 的比例,用于OSA中的MASLD.
- 评估这些指标与阿氨酸转移酶 (ALT) 的联合预测性能.
主要方法:
- 追溯队列研究分析了133名OSA患者的数据.
- 分为单独OSA和OSA与MASLD组的分层.
- 后勤回归和ROC曲线分析以确定风险因素和预测性能.
主要成果:
- 有104名 (78.2%) OSA患者患有MASLD.
- TyG-BMI和TG/HDL-C比率是MASLD的重要预测因素.
- 将TyG-BMI或TG/HDL-C比率与ALT相结合,显著提高了MASLD预测的准确性.
结论:
- TyG-BMI和TG/HDL-C比率是OSA中有效的MASLD预测因素.
- 与ALT相结合的模型提供了增强的预测准确性.
- 这些指数对于在资源有限的环境中对MASLD风险分层有价值.
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