慢性间歇性缺氧与MASLD和阻塞性睡眠呼吸暂停患者纤维化之间的关系
Sidem Gul1, Songul Ozyurt2, Caglayan Keklikkiran3
1School of Medicine, Recep Tayyip Erdoğan University Faculty of Medicine, 53100 Rize, Turkey.
Journal of clinical medicine
|March 14, 2026
概括
阻塞性睡眠呼吸暂停 (OSA) 与诸如代谢功能障碍相关的脂肪性肝病 (MASLD) 和纤维化等肝病有关. 虽然OSA的严重程度最初与这些肝脏问题相关,但在调整后,肥胖和代谢综合征是主要的驱动因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 肺部病理学 肺部病理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 涉及睡眠期间反复出现的呼吸中断和氧气下降.
- 来自OSA的慢性间歇性缺氧 (CIH) 可能导致与代谢功能障碍相关的脂肪性肝病 (MASLD) 和肝纤维化.
- 这项研究调查了OSA严重程度,低氧化和MASLD/纤维化之间的联系.
研究的目的:
- 为了评估OSA严重程度和低氧度指数与MASLD和肝纤维化之间的关联.
- 在评估OSA的患者中确定MASLD和纤维化的独立预测因子.
- 为了向临床实践提供有关OSA患者肝脏评估的信息.
主要方法:
- 预计将招募400名怀疑患有OSA的成年人.
- 夜间的多睡眠记录记录呼吸暂停-呼吸暂停指数 (AHI) 和氧气脱度指数 (ODI).
- 暂时弹性扫描 (FibroScan) 用于评估MASLD (CAP) 和纤维化 (LSM).
主要成果:
- MASLD的患病率为76%,纤维化患病率为34.5%.
- 纤维化患者显示出较高的AHI,ODI和较低的最低SPO2.
- 多变量分析显示BMI和代谢综合征是MASLD和纤维化疾病的独立预测因素.
结论:
- 观察到OSA严重程度/低氧化和肝病之间的初始关联.
- 肥胖 (BMI) 和代谢综合征独立预测OSA患者的MASLD和纤维化.
- 建议对OSA患者进行肝脏评估,特别是那些高BMI和代谢综合征患者.
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