在黎巴嫩患者中结直肠癌中BRAF突变的患病率:一项描述性研究
Christelle Rahme1, Bassil Josianne2, Trak Smayra Viviane3
1Department of Internal Medicine, College of Medicine, Central Michigan University, Mount Pleasant Campus, Mount Pleasant, MI 48859, USA.
Journal of clinical medicine
|March 14, 2026
概括
BRAF基因突变发生在5.3%的黎巴嫩结直肠癌患者中,与右侧瘤和微卫星不稳定性相关. 需要进一步的研究来确认与其他临床因素的关联.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 在结直肠癌 (CRC) 中的BRAF基因突变具有预后和治疗意义.
- 关于中东地区,特别是黎巴嫩的BRAF突变患病率的数据有限.
- 这项研究调查了黎巴嫩CRC患者的BRAF突变频率及其临床相关性.
研究的目的:
- 为了确定在黎巴嫩患有转移性结直肠癌的患者中BRAF基因突变的患病率.
- 探索BRAF突变与各种临床病理变量之间的潜在相关性.
主要方法:
- 对190名黎巴嫩转移性结直肠癌患者样本 (2015-2021) 的回顾性分析.
- 在两个分子实验室的基因分析中确定了BRAF突变状态.
- 从计算机化医疗记录中提取的临床数据;使用SPSS进行的统计分析.
主要成果:
- 在190名患者中有10名 (5.3%) 检测到BRAF突变.
- 在BRAF突变和右侧瘤之间发现了显著的正相关性 (p=0.001).
- 在BRAF突变和微卫星不稳定性之间观察到正相关性 (p=0.004).
结论:
- 在黎巴嫩CRC中BRAF突变的流行率为5.3%.
- 建议BRAF突变,结肠侧向性和微卫星不稳定性之间存在相关性.
- 在BRAF突变与年龄,性别,组织学差异化或腹转移之间没有发现统计学上显著的关联.
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