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预测和管理肝细胞癌在肝移植后复发:一个单一中心的经验 2012-2024年

Jesse Civan¹, Madison Force¹, Ali Raza Shaikh²

¹Division of Gastroenterology and Hepatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

|March 14, 2026

概括

肝移植后肝细胞癌复发发生在10.9%的患者中. RETREAT评分显示,识别低风险患者的能力有限,这表明广泛的监测比肝移植后肝细胞癌的个性化策略更好.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
在瘤学瘤学.

背景情况:

肝细胞癌 (HCC) 是美国癌症死亡的主要原因.
整形肝移植 (OLT) 为选定的HCC患者提供了治愈的选择.
后OLT HCC复发影响高达15%的接受者,需要有效的监测.

研究的目的:

评估RETREAT评分在预测后OLT HCC复发中的有效性.
评估OLT后管理HCC复发的结果和挑战.
确定OLT后HCC复发的最佳监测策略.

主要方法:

对923名OLT接收者的单一中心回顾分析 (2012-2024年).
通过组织学或LI-RADS 5成像证实HCC诊断.
计算所有患者的RETREAT评分,以评估复发风险.

主要成果:

在329名HCC患者中,36人 (10.9%) 经历了OLT后复发.
复发与活跃瘤相关的扩散,超出米兰标准,微血管入侵,较大的瘤大小和更高的RETREAT得分.
很大一部分 (三分之一) 的复发病例具有较低的RETREAT分数 (0或1),限制了其预测价值.

结论:

后OLT HCC复发率和系统治疗挑战与现有文献一致.
RETREAT评分显示敏感性有限,预测价值为负,用于识别低风险患者.
广泛的监测策略可能优于基于低RETREAT分数的个性化方法,用于OLT后HCC复发.

关键词:

在HCC中,HCC是HCC.HCC的复发情况在RETREAT分数中,我们可以获得RETREAT分数.肝细胞癌是肝细胞癌.免疫疗法免疫疗法肝移植肝移植肝移植

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