针对前列腺癌中的雄激素受体信号的生物活性天然产品:系统性审查
Febby Pratama1, Dhania Novitasari1, Richa Mardianingrum2
1Departement of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Ir. Soekarno KM 21, Jatinangor 45363, Indonesia.
Cancers
|March 14, 2026
概括
天然产品在准前列腺癌方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 自然产品化学 自然产品化学
- 分子生物学分子生物学
背景情况:
- 前列腺癌是男性癌症死亡的主要原因.
- 雄激素受体 (AR) 信号驱动前列腺癌,特别是抵抗割的前列腺癌 (CRPC).
- 在CRPC中治疗耐药性需要针对AR途径的新型治疗策略.
研究的目的:
- 系统地审查针对雄激素受体 (AR) 信号轴的天然产品.
- 巩固自然化合物作为AR驱动前列腺癌的潜在替代品的证据.
- 探索自然产品调节CRPC中的AR信号的机制.
主要方法:
- 在PubMed,Scopus和ScienceDirect中使用PRISMA指南进行系统的文献搜索.
- 对15项关于天然化合物和AR信号的原始研究的定性分析.
- 确定研究自然产品在调节AR中的疗效和机制的研究.
主要成果:
- 自然产品使用各种机制来禁用AR信号.
- 诸如新氧化素和α-乙烯等化合物抑制AR的表达和活性.
- α-曼戈斯降解AR-V7,而曼扎明A通过E2F8.8抑制AR生物合成.
- 其他化合物抑制5-α-减少酶或激活ZIP9以诱导亡.
结论:
- 自然产品为向前列腺癌中AR信号提供了潜在的生物活性替代品.
- 这些化合物表现出各种机制,包括AR抑制,降解和相关途径的抑制.
- 本综述提供了一个临床前框架,用于识别天然物质,以对抗AR驱动的CRPC.
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