用血液生物标志物,心声学和F-FDG PET/CT:试点研究使用左乳癌患者辐射诱导的亚临床心脏变化的前性多式评估18
Yong Kyun Won1, Jeong Won Lee2, Sang Mi Lee2
1Department of Radiation Oncology, Soonchunhyang University Cheonan Hospital, 31, Sooncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea.
左乳腺癌的放射治疗可能会导致持续的亚临床心肌变化. 生物标志物和成像显示治疗后心肌代谢和功能的持续变化.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 左乳腺癌患者经常接受术后放射治疗 (RT).
- 心脏健康可能会受到RT的影响,需要对亚临床变化进行监测.
研究的目的:
- 在左乳腺癌患者的RT后调查无症状的显微心肌变化.
- 评估心脏功能和新陈代谢使用多模式技术后RT.
主要方法:
- 对16名接受RT的左乳癌患者进行前性研究.
- 心脏评估包括生物标志物,全球纵向菌株 (GLS) 和18F-FDG PET/CT在RT前后进行.
- 在多个时间点对心脏参数进行比较分析,长达48周.
主要成果:
- 观察到炎症生物标志物的暂时变化;热素T和ST2显示持续的变化.
- 在RT后检测到GLS和心肌代谢比率的显著差异.
- 心肌代谢的改变在RT后持续了长达一年.
结论:
- 在左乳腺癌的RT后,亚临床心肌变化可能会持续长期.
- 这些持续的亚临床变化的临床意义需要进一步研究.
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