头腺状囊性癌初级手术后持续的长期风险:竞争风险和条件估计
Ivica Lukšić1,2, Marko Tarle1,3, Marina Raguž4,5
1Department of Maxillofacial and Oral Surgery, Dubrava University Hospital, 10000 Zagreb, Croatia.
Cancers
|March 14, 2026
概括
头部和部腺囊性癌症 (HNAdCC) 患者面临着持续的长期复发和死亡风险,许多失败发生在五年后. 建议进行终身监测,以检测晚期远程转移.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症流行病学 癌症流行病学
背景情况:
- 头部和部腺囊性癌 (HNAdCC) 具有惰的生长模式,但具有晚期复发和死亡的持续风险.
- 关于非常长期结果的数据有限,特别是在考虑竞争性死亡风险时.
研究的目的:
- 在HNAdCC中描述晚期故障模式.
- 分析相互竞争的死亡原因.
- 为HNAdCC.进行初级手术后提供临床可解释的长期风险估计.
主要方法:
- 回顾性单中心队列研究HNAdCC患者治疗治疗意图手术 (1984-2020).
- 卡普兰-梅尔总生存率 (OS) 和癌症特定生存率 (CSS) 的方法.
- 竞争风险和故障模式的累积发病率函数,包括5年基准分析;评估条件死亡率和限制平均存活时间 (RMST).
主要成果:
- 在57名患者中,33.3%的患者经历了第一次失败,远程转移是最常见的;36.8%的失败发生在5年后.
- 在25岁时,OS为37.5%,CSS为51.7%. 疾病相关死亡的累计发病率为41.7%,而其他原因死亡的发病率为20.9%.
- 年龄较大,T类高级和围神经侵入与更糟糕的生存结果有关;在5年幸存者中,25岁时与疾病有关的死亡的条件风险仍然为32.7%.
结论:
- HNAdCC存在着持续的长期风险,几十年来出现了显著的晚期失败和相应的死亡率.
- 条件和RMST估计提供以患者为中心的指标,支持终身,风险适应的监测.
- 监测应侧重于检测远程转移,因为它们在疾病晚期的高发病率.
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