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Updated: Mar 15, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

独特的NK细胞特征定义了HPV阳性与HPV阴性头癌的预后

Rui Li^1,2, Fangjia Tong², Huan Liu^2,3

¹Department of Neurosurgery, Shenzhen Third People's Hospital, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China.

|March 14, 2026

概括

在头角平状细胞癌 (HNSCC) 中,自然杀手 (NK) 细胞的活性因人乳头瘤病毒 (HPV) 状态而异. 一个特定的NK细胞子集预测HPV阳性HNSCC的更好的生存率,而一个不同的机制驱动HPV阴性HNSCC的免疫逃避.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

人类乳头瘤病毒 (HPV) 状态显著影响头部和部状细胞癌 (HNSCC) 的预后.
对HPV阳性 (HPV+) 与HPV阴性 (HPV-) HNSCC存活率差异的潜在免疫机制尚不清楚.
鉴定瘤透自然杀手 (NK) 细胞的特征对于确定治疗点至关重要.

研究的目的:

分析HPV分层HNSCC中的NK细胞格局.
识别与HPV状态和患者存活率相关的NK细胞子集.
发现HNSCC免疫疗法的新疗法标.

主要方法:

重新分析单细胞RNA测序数据从HPV状况分层的HNSCC患者.
识别NK细胞子集和伪时间轨迹推断.
细胞与细胞相互作用分析,免疫组织化学验证和TCGA数据评估用于预后关联.

主要成果:

确定了四种不同的NK细胞子集:适应性,杀死细胞,CD56bright和病毒反应性.
一个细胞毒性CX3CR1+KLRB1dimNK子集被丰富在HPV+HNSCC中,并与有利的生存率相关.
HPV-HNSCC表现出高调的CLEC2C/CLEC2D配体,在NK细胞上激活KLRB1,与抑制的NK活性和更差的预后相关.

结论:

在HNSCC中NK细胞的功能是由HPV状态二分法调节的.
CX3CR1+KLRB1dim NK细胞子集是HPV+HNSCC的潜在预后生物标志物.
CLEC2-KLRB1轴代表HPV-HNSCC中可向的免疫逃避机制,这表明HPV分层免疫疗法的发展.

关键词:

头部和部癌症头部和部癌症人类乳头瘤病毒人类乳头瘤病毒免疫疗法免疫疗法自然杀手细胞是自然杀手细胞.瘤微环境是一个微环境.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...