前列腺测试的临床效用:一项前性研究表明,在评估前列腺癌的男性中,减少不必要的MRI和活检
Kambiz Rahbar1,2, Martin Bögemann2,3, Philipp Papavasilis2,3
1Department of Nuclear Medicine, University Hospital Muenster, 48149 Muenster, Germany.
Cancers
|March 14, 2026
概括
PROSTest是一种新的液体活检测方法,在检测前列腺癌 (PCa) 方面具有很高的准确性. 这种血液检测可以帮助分组患者,可能减少不必要的活检,并改善临床上显著的PCa的早期检测.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物标志物发现发现
背景情况:
- 早期发现前列腺癌 (PCa) 可以改善结果.
- 多参数MRI (PI-RADS) 有助于做出活检决定.
- PROSTest是一种新型的30基因mRNA液体活检,用于PCa检测.
研究的目的:
- 评估PROSTest作为一个预活检分类工具.
- 评估PROSTest对临床显著PCa (csPCa) 的敏感性.
- 确定PROSTest在完善活检决策中的实用性.
主要方法:
- 对111名接受诊断工作的男性进行前性研究.
- 在活检之前,从外周血液中取出PROSTest液体活检.
- 基因表达数据的机器学习分析;切断值≥50.
主要成果:
- PROSTest显示了91%的整体准确性和89%的负预测值 (NPV).
- 在没有PCa的男性中,在活检时 (17),47%的男性是PROST测试负的.
- 高诊断准确性 (99%) 通过活检确认的PCa.
结论:
- PROSTest显示出作为预活检分类试验的巨大潜力.
- 该测定有助于识别可能不需要立即活检的男性.
- PROSTest补充了现有的查工具,如PSA和PI-RADS.
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