从黑盒子到生物洞察力:注意力开启了肺癌中的多奥米克动态
Yuhang Huang1, Yungang He2, Liyan Zeng2
1Institutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032, China.
Cancers
|March 14, 2026
概括
通过整合多omics数据,AttentioFuse提高了非小细胞肺癌 (NSCLC) 的预后. 这种可解释的深度学习模型为精密疗法提供了生物学基础的见解,改善了临床决策.
科学领域:
- 计算生物学是一种计算生物学.
- 基因组学就是基因组学.
- 机器学习在瘤学中
背景情况:
- 非小细胞肺癌 (NSCLC) 亚型,肺腺癌 (LUAD) 和状细胞癌 (LUSC),具有不同的分子形状,影响预后和治疗.
- 深度学习模型为NSCLC提供了高预测准确度,但缺乏透明度,阻碍了临床采用.
研究的目的:
- 开发AttentioFuse,这是一个可解释的深度学习框架,用于在LUAD和LUSC中准确的预后和治疗.
- 通过使用Reactome指导的策略来整合多omics数据,以提高生物洞察力.
主要方法:
- AttentioFuse利用双相学习与欧米特异性编码器和层次注意力机制来进行动态层贡献分析.
- 综合解释性结合了DeepSHAP和全球关注权重,用于基因到通路的解释.
- 两种变体,AtentioFuse-3F和AtentioFuse-5X,被评估为歧视和等级解释.
主要成果:
- 在TCGA LUAD/LUSC队列上,AttentioFuse实现了最先进的TNM分期性能.
- 确定了关键的生物学见解,包括泛NSCLC AKT/mTOR代谢调节和组织学特定的Notch信号.
- 发现了与发育活性,微生物群相关转移和细胞外矩阵重塑相关的途径.
结论:
- AttentioFuse-5X成功地平衡了预测准确性与层次的路径级解释.
- 该框架将黑子深度学习预测转化为可操作的,生物知情的瘤学决策支持.
更多相关视频
07:39The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
10.0K
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
2.3K
相关概念视频
02:02Genomics
41.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.4K
02:17The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
02:53Adaptive Mechanisms in Cancer Cells
7.3K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K