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Updated: Mar 15, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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通过PROTAC介导的MDM2的向降解诱导了骨髓瘤细胞中的瘤抑制信号

Yeongji Kim1, Jin-Woo Kim2, Junwon Choi3

  • 1Department of Orthopaedic Surgery, CHA Bundang Medical Center, School of Medicine, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of Korea.

Cells
|March 14, 2026
PubMed
概括

新的蛋白质溶解向嵌合体 (PROTACs) 有效降解MDM2,这是骨髓瘤中关键蛋白质. 这种方法显着有望通过重新激活瘤抑制路径来治疗这种侵袭性骨癌.

关键词:
MDM2 降解降解的方法这就是PROTAC.癌症治疗疗法 癌症治疗骨质肉瘤是骨质肉瘤的一种疾病.在p53路径中.

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