月经排水在子宫内膜异位症的发病和诊断中的作用 - - 一项系统性审查
Rafał Watrowski1,2, Stoyan Kostov3,4, Eva Tsoneva4,5
1Department of Gynecology, Helios Hospital Müllheim, Heliosweg 1, 79379 Müllheim, Germany.
Diagnostics (Basel, Switzerland)
|March 14, 2026
概括
月经排泄物 (ME) 对诊断子宫内膜异位症有希望,反映了关键疾病机制. 对芳酶和TGF-β1的测定显示出高精度,但需要进一步验证临床使用.
科学领域:
- 妇科 妇科 妇科 妇科
- 生物标志物发现发现
- 诊断发展 诊断发展
背景情况:
- 子宫内膜异位症给个人和社会带来了巨大的负担.
- 诊断往往会延迟7-10年,这突出了严重的未满足需求.
- 月经排泄物 (ME) 是一种具有诊断潜力的可访问的生物流体.
研究的目的:
- 系统地审查ME在子宫内膜异位症中的病理生理学相关性.
- 评估ME对子宫内膜异位症的诊断潜力.
- 为了识别ME内的关键生物标志物,用于检测子宫内膜异位症.
主要方法:
- 在多个数据库中按照PRISMA 2020指南进行系统的文献搜索.
- 包括原始研究分析人类ME或ME衍生细胞在妇女与子宫内膜异位症对照对照.
- 提取研究设计,分析方法,诊断准确度指标,机械途径和偏差风险.
主要成果:
- 三十五项研究证实ME反映了主要的子宫内膜异位症机制,如免疫失调和受损的决定性.
- 芳酶mRNA (AUC0.977),TGF-β1 (AUC0.973),和IGFBP1 (AUC0.92) 显示出高的诊断准确性. 这两种药物具有非常高的治疗效果.
- 目前所有的诊断评估都是基于病例控制研究,没有前性验证.
结论:
- 月经排泄物是一种生物相关的,对子宫内膜异位症的非侵入性生物标本.
- 反映类固醇和生长因子通路的生物标志物显示出最高的诊断性能.
- 基于ME的诊断的标准化和前性验证对于临床采用至关重要.
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