在评估上升性大动脉弹性属性的ECG同步计算机断层扫描:临床和实验研究研究
Svetlana I Sazonova1, Viktor V Saushkin1, Dmitri S Panfilov1
1Cardiology Research Institute, Branch of the Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences" (Cardiology Research Institute, Tomsk NRMC), 111a Kievskaya, 634012 Tomsk, Russia.
电脑心电图同步CT可以评估大动脉弹性,与ex vivo特性相关. 然而,这些CT衍生的弹性指数并不能预测动脉瘤进展在患有上升性大动脉扩张的患者.
科学领域:
- 心血管成像 - 心血管成像
- 生物机械工程 生物机械工程
- 医学诊断 医学诊断 医学诊断
背景情况:
- 电脑心电图同步CT显示出评估大动脉弹性和变形性能的潜力.
- 目前,有限的证据支持这种成像技术的实际应用.
- 上升性大动脉扩张 (AsAo) 是一种需要可靠的评估方法的疾病.
研究的目的:
- 调查CT衍生的上升大动脉弹性指数和ex vivo生物力学特性之间的关联.
- 评估这些CT衍生指数在非手术患者的预测潜力.
主要方法:
- 71名AsAo扩张患者和29名对照患者接受了ECG同步CT-aortography.
- 在42名手术患者中,CT衍生的参数 (应变,顺应,刚性) 与ex vivo生物力学特性进行了比较.
- 在29名非手术患者中,CT弹性指数的预后值在36个月内被评估.
主要成果:
- 在CT衍生菌株/延展性和ex vivo相对菌株之间观察到适度的相关性.
- 与对照人群相比,CT证实扩大大动脉的刚性增加和弹性降低.
- 在非手术患者中,CT弹性参数没有预测不良动脉瘤进展.
结论:
- 电脑心电图同步CT可以评估大动脉弹性,显示与ex vivo生物力学性质的相关性.
- CT衍生弹性指数目前缺乏预后价值来预测小上升大动脉动脉瘤的生长.
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