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聚-D,L-乳酸填充剂通过改善与年龄相关的毛囊衰退来恢复头发的厚度和光泽

Seyeon Oh^1,2, Hosung Choi³, Jino Kim^1,4,5

¹Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.

International journal of molecular sciences

|March 14, 2026

概括

聚-D,L-乳酸 (PDLLA) 填充剂通过减少氧化应激和恢复皮肤乳头细胞功能来对抗头发衰老. 这种治疗促进了头发的生长,并改善了老年小鼠的头发质量,为与年龄相关的头发变薄提供了潜在的机会.

科学领域:

皮肤病学皮肤病学
再生医学是一种再生医学.
生物材料科学生物材料科学

背景情况:

头发老化涉及由于氧化压力的毛囊和脂质腺衰退,导致头发变薄和光泽减少.
皮肤乳头细胞 (DPC) 衰老会影响类似胰岛素的生长因子-1 (IGF-1) 的分泌和角质细胞的增殖,从而导致头发衰老.

研究的目的:

研究聚D,L-乳酸 (PDLLA) 填充剂对与年龄相关的头发变化的修复作用.
评估PDLLA填充剂对抗氧化应激和毛囊细胞衰老的潜力.

主要方法:

评估了PDLLA填充剂对衰老的人类DPC和老鼠皮肤中氧化应激标志物 (8-基-2'-脱氧氨酸) 的影响.
评估了PDLLA填充剂对DPC和毛囊角质细胞 (HFK) 增殖和分化标记物的影响.
研究了PDLLA填充剂对老年小鼠头发轴角质蛋白,皮质完整性,脂质腺功能和头发光泽的影响.

主要成果:

PDLLA填充剂降低了氧化应激,并减轻了衰老的DPC中的细胞循环逮捕,上调了IGF-1分泌.
来自PDLLA处理的DPC的条件介质在老化的HFK中增强了增殖和氨酸表达.
在老年小鼠中,PDLLA填充剂降低了氧化应激,恢复了DPC增殖,增加了IGF-1,增强了HFK增殖,调节了关键质蛋白,改善了皮质完整性,减弱了卵泡小型化,增强了脂质腺活动和头发光泽.

结论:

PDLLA填充剂有效地改善与衰老相关的表型和毛囊和脂质腺的功能衰退.
PDLLA填充剂显示出作为与年龄相关的脱发和头发质量恶化的干预措施的巨大潜力.

关键词:

头发的老化头发的老化毛囊老化发的衰老头发轴上的角质 (keratins) 是一种质.头发发光发光的时间聚-D,L-乳酸的乳酸是什么

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