在PVN中表达的Piezo1通道在调节同情神经活动和大脑动脉血压中的作用
Yue Chen1, Wei Guo2, Jichun Wang1
1Department of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.
International journal of molecular sciences
|March 14, 2026
概括
阻断对腹腔内核 (PVN) 中机械敏感的Piezo1通道会增加交感神经活动和血压. 在PVN神经元中的Piezo1通道调节心血管功能.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 细胞生物学 细胞生物学
背景情况:
- 众所周知,机械敏感的Piezo1通道调节疼痛,胰岛素分泌和血管度.
- 它们在自主准腹膜核 (PVN) 中的作用及其对交感外流和心血管功能的影响尚未研究.
研究的目的:
- 研究Piezo1通道在PVN中的表达和功能.
- 确定PVN Piezo1通道在调节交感外流和心血管功能的作用.
主要方法:
- 在麻醉的雄性大鼠中,单边PVN微注射Piezo1通道阻塞剂 (Dooku1,GsMTx4) 和激活剂 (Yoda1,Jedi2).
- 测量交感神经活动 (RSNA) 和平均动脉压 (MAP).
- 在PVN中对Piezo1表达的西部斑,qRT-PCR和免疫光分析.
主要成果:
- 在Piezo1阻断剂Dooku1和GsMTx4的PVN微注射剂剂量取决于增加RSNA和MAP.
- 对Piezo1激活剂Yoda1和Jedi2的PVN微注射没有显著改变RSNA或MAP.
- 在PVN中检测到丰富的Piezo1mRNA和蛋白质,其表达在预交感神经元中,向正面腹侧髓投射.
结论:
- 皮埃佐1通道以自主PVN表示.
- 在PVN中抑制Piezo1通道增加了交感外流,并提高了血压.
- 在PVN神经元中的Piezo1通道在调节交感活动和心血管平衡方面发挥着至关重要的作用.
更多相关视频
06:30Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
8.3K
07:51Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
Published on: September 22, 2011
29.6K
相关概念视频
01:18Neural Regulation of Blood Pressure
8.1K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
8.1K
01:12Mechanically-gated Ion Channels
8.0K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
8.0K
01:27Regulation of the Cardiovascular System
4.8K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.8K
01:31Regulation of Heart Rates
4.4K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
4.4K
01:31Sympathetic Signaling
2.8K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
2.8K
01:18Disorders of the Autonomic Nervous System
1.8K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
1.8K