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儿科性淋巴毒性治疗和未成熟的丸组织银行后的青春期发育
Emily Delgouffe1, Marius Regin1,2, Veerle Vloeberghs3
1Genetics, Reproduction and Development (GRAD) Research Group, Brussels Health Campus/Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.
International journal of molecular sciences
|March 14, 2026
概括
丸组织储存 (TTB) 是一种安全的生育保护方法,用于接受淋巴毒性治疗的青春期前男孩. 研究表明,TTB不会损害丸的功能或结构,使正常的青春期和丸激素的产生.
科学领域:
- 生殖医学 生殖医学
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
背景情况:
- 儿科性腺毒性治疗对男性生育能力构成风险.
- 关于治疗后青春期发育的前性数据有限.
- 未成熟的丸组织储存 (TTB) 是一个实验性的生育保护选项,用于青春期前的男孩,但其长期的安全性和与治疗的相互作用需要进一步调查.
研究的目的:
- 系统地评估TTB对治疗恶性或非恶性疾病的男孩青春期发育的长期安全性和影响.
- 评估性腺毒性治疗和TTB对丸结构,功能和荷尔蒙特征的影响.
- 在这个群体中提供关于青春期发展的多维数据.
主要方法:
- 23名男孩 (2017-2025) 的单中心前性队列研究,其中15名接受了TTB.
- 重复的评估包括青春期阶段,丸体积,辅酶体完整性,生殖激素 (黄蛋白激素,卵泡刺激激素,B抑制素,抗穆勒激素,丸激素),骨年龄和骨密度.
- 随访时间中位数为4.0年.
主要成果:
- 淋巴细胞毒性治疗,特别是骨髓缩性调节,与青春期后丸体积减少和荷尔蒙特征变化 (LH/FSH升高,抑制B降低) 有关.
- 反米勒尔激素水平保持稳定.
- 所有患者都经历了自发性青春期,并保持了的产生.
- 丸膜完整性不受活检的影响;活检和非活检丸之间的体积减少是可比的.
结论:
- TTB似乎是安全的,对丸结构或功能没有明显的不良影响.
- 该程序不会阻碍自发性青春期或丸激素的产生.
- 需要进行更大规模的多中心前性研究来验证这些发现,并确认儿童群体的TTB安全性.
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