米和阳光干燥的人参:化学成分和对性结肠炎的保护作用的比较研究
Qi Chu1, Yidan Zhang1, Junbao Li1
1School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
International journal of molecular sciences
|March 14, 2026
概括
与日晒干燥的人参 (SDG) 相比,大米炸人参 (RFG) 显示出优异的抗炎和抗性结肠炎 (UC) 作用. RFG调节肠道微生物群和关键信号通路,提供对UC的增强保护.
科学领域:
- 药理学和中国传统医学
- 胃肠道学和免疫学
- 自然产品化学 自然产品化学
背景情况:
- 人参 (Panax ginseng) 是一种具有抗炎和抗性结肠炎 (UC) 功能的传统中国药物.
- 假设米人参 (RFG) 加工可以通过丰富稀有人参来增强其治疗效果.
研究的目的:
- 为了比较RFG和日晒 ginseng (SDG) 的化学成分.
- 评估RFG在体外和体内对UC的保护作用.
- 阐明RFG治疗作用的基本机制.
主要方法:
- 使用LC-MS和MS-DIAL进行RFG和SDG的化学分析.
- 在体外评估使用脂聚糖 (LPS) 诱导的Caco-2细胞.
- 在体内使用硫酸 (DSS) 诱导的UC小鼠模型进行体内评估.
- 代谢学,网络药理学和西式抹杀分析.
主要成果:
- 大米显著改变了人参的化学成分,31种化合物增加,33种化合物减少.
- 在Caco-2细胞和DSS诱导的UC小鼠中,RFG证明了增强的保护,改善了肠道屏障的完整性并减少了炎症.
- RFG调节了肠道微生物群,改变了脂质代谢,并抑制了PI3K-Akt和NF-κB信号通路.
结论:
- 与SDG相比,RFG表现出更强的抗炎和抗UC作用.
- RFG的有效性与其改变的化学特征,肠道微生物群和脂质代谢的调节以及关键炎症信号通路的抑制有关.
- RFG代表了性结肠炎的一个有前途的治疗药物.
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