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在前列腺癌中,淋巴血管入侵的干扰素-响应的转录学签名

Cagdas Aktan¹, Christina M Breneman², Okan Argun²

¹Department of Medical Biology, Faculty of Medicine, Bandirma Onyedi Eylul University, Balikesir 10250, Türkiye.

International journal of molecular sciences

|March 14, 2026

概括

前列腺癌中的淋巴血管侵入 (LVI) 与干扰素信号通路有关. 这一发现为LVI提供了新的预后洞察力和潜在的治疗点,独立于瘤等级和阶段.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

淋巴血管入侵 (LVI) 是前列腺癌的不良预后指标.
由于瘤等级和阶段等混因素,其分子驱动因素的了解很少.

研究的目的:

为了确定前列腺癌中LVI的分子驱动因素.
调查LVI相关基因表达特征的预后意义.
探索已识别的基因的调节机制.

主要方法:

对403个TCGA-PRAD样本进行了混调整的转录基因分析.
对格里森得分和病态T阶段进行调整的差异基因表达分析.
生物化学无复发生存的多变量后勤和考克斯比例危险模型.
多omics集成 (甲基化和表达数据).

主要成果:

在多变量调整后,有129个基因独立与LVI相关.
这一基因组为干扰素α/β信号传递和抗病毒反应途径进行了丰富.
这种特征的综合评分预测了生物化学复发风险的降低 (aHR=0.911,p=0.033).
对关键的干扰素基因观察到微妙促进物低甲基化和甲基化表达相关性.

结论:

一个强大的干扰素反应转录特征独立地定义了前列腺癌中的LVI.
这种签名提供了超越标准临床病理因素的预后信息.
这些发现完善了对LVI的生物学理解,并提出了新的治疗点.

关键词:

淋巴血管侵入淋巴血管侵入前列腺癌是前列腺癌.文字转录文字转录文字转录

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