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相关概念视频

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
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基于TCGA的空间分析揭示了外围CD147表达在侵袭性瘤前线作为OSCC的预后指标.

Felix Nieberle1, Steffen Spoerl1, Quirin Strotzer2

  • 1Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

International journal of molecular sciences
|March 14, 2026
PubMed
概括
此摘要是机器生成的。

低CD147糖蛋白表达在口腔状细胞癌侵袭前面表明更好的生存率. CD147 是一个CD147 CD147 是一个CD147

关键词:
基本原产地 基本原产地CD147 是一个CD147 CD147 是一个CD147在TCGA中,TCGA就是TCGA.生物标志物生物标志物免疫逃避 免疫逃避口腔状细胞癌的癌症.预后 预后 预后治疗耐药性 治疗耐药性组织微阵列.瘤微环境是一个微环境.

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科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 免疫学 免疫学 免疫学

背景情况:

  • 口腔状细胞癌 (OSCC) 是癌症死亡的主要原因,预后工具有限.
  • CD147是一种膜糖蛋白,涉及瘤进展,免疫逃避和治疗耐药性.

研究的目的:

  • 调查不同OSCC区的CD147表达的预后和预测价值.
  • 探索CD147与生存,临床病理参数和治疗反应的关联.

主要方法:

  • 在229个OSCC患者样本上进行免疫组织化学测试,以评估CD147在瘤中心,周边和相邻的粘膜中的表达.
  • 包括卡普兰-梅尔和考克斯回归在内的统计分析.
  • 使用TCGA,UALCAN,TISIDB和GTEx数据集进行转录和免疫学分析.

主要成果:

  • 瘤侵入性前部的低CD147表达是改善整体存活率的独立预测因素.
  • 瘤中心或粘膜中的CD147表达没有显示出预后价值.
  • 在CD147表达和辅助治疗反应之间没有发现显著的关联.
  • TCGA数据证实了CD147的过度表达及其与免疫抑制和治疗耐药性的联系.

结论:

  • 瘤外围的CD147表达是OSCC的分区特异性预后标志物.
  • CD147在免疫调节和治疗耐药性的作用表明其作为生物标志物和治疗点的潜力.