综合非向和向代谢学揭示了益生菌补充剂和酸奶之间明显的生物活性代谢物概况
Sang Hyeon Noh1, Su-Hyun Kim1, Do Hoon Kwon1
1Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.
International journal of molecular sciences
|March 14, 2026
概括
益生菌补充剂 (PS) 和酸奶 (YG) 具有不同的生化特征. PS显示出更高的抗氧化和抗糖化活性,与特定的氨基酸和醇衍生物有关.
科学领域:
- 生物化学 生物化学
- 代谢学 代谢学 代谢学
- 食品科学 食品科学 食品科学
背景情况:
- 益生菌是受欢迎的促进健康的药物,以补充剂 (PS) 或酸奶 (YG) 的形式消费.
- 对于PS和YG的生物化学特征,存在有限的系统比较.
- 了解这些差异对于优化健康益处至关重要.
研究的目的:
- 使用综合代谢学,全面比较PS和YG的代谢物概况.
- 为了确定区分PS与YG的特定标记代谢物.
- 评估体外抗氧化和抗糖活性及其与已识别的代谢物相关性.
主要方法:
- 利用集成的非向和向代谢学来分析PS和YG.
- 鉴定和量化了两种益生菌形式之间的差异性代谢物.
- 对抗氧化剂和抗糖化活性进行了体外测定.
主要成果:
- 在PS中,氨基酸,溶解脂,乙酸,酸和醇衍生物的含量较高.
- YG含有更多的碳水化合物,乙卡尼丁,脂,丁酸盐和肌酸.
- 鉴定了27种特定于PS的和17种特定于YG的标记代谢物.
- 与YG相比,PS表现出明显更高的抗氧化和抗糖活性.
- 印衍生物 (例如,印-3-酸) 与PS的抗糖化活性有关.
结论:
- PS和YG具有不同的生化成分和代谢物概况.
- 在PS中的特定氨基酸和醇衍生物有助于其增强的生物活性.
- 已识别的标记代谢物和生物活性化合物为PS和YG之间的功能差异提供了洞察力.
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