Jove
Visualize
联系我们

相关概念视频

Pedigree Analysis01:35

Pedigree Analysis

Overview
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pharmacogenetic Analysis of Variants in IL-6 Signaling and Response to Modern Therapeutic Approaches in Greek Patients with Atopic Dermatitis.

Genes·2026
Same author

Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases.

International journal of molecular sciences·2025
Same author

aPEAch: Automated Pipeline for End-to-End Analysis of Epigenomic and Transcriptomic Data.

Biology·2024
Same author

Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity.

Genes and immunity·2024
Same author

Association between variants in <i>TCF7L2</i>, <i>CTRB1/2</i>, and <i>GLP-1R</i> genes and response to therapy with glucagon-like peptide-1 receptor agonists.

Postgraduate medicine·2024
Same author

Disentangling the complexity of psoriasis in the post-genome-wide association era.

Genes and immunity·2023
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jul 3, 2026

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation
07:11

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

22.3K

单细胞cis-Mendelian随机化揭示了底层的细胞特异性遗传机制 亚托皮炎.

Charalabos Antonatos1, Yiannis Vasilopoulos1

  • 1Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece.

International journal of molecular sciences
|March 14, 2026
PubMed
概括

亚托匹性皮肤炎 (AD) 风险基因表现出多样化,细胞特异性的影响. 了解这些免疫细胞特异性遗传联系为AD提供了新的治疗点.

科学领域:

  • 遗传学 是一个遗传学.
  • 免疫学 免疫学 免疫学
  • 皮肤病学 皮肤病学

背景情况:

  • 亚托匹性皮肤炎 (AD) 是一种具有复杂遗传基础的慢性炎症性皮肤病.
  • 免疫系统的失调是AD病原体的核心.

研究的目的:

  • 为了确定细胞特异性阿托皮性皮肤炎的遗传驱动因素.
  • 解决与AD相关的不同免疫细胞类型中的遗传媒介转录效应.

主要方法:

  • 综合单细胞表达定量特征位点 (eQTLs) 来自14种具有AD的免疫细胞类型的全基因组关联研究 (GWAS) 数据.
  • 采用了一个两样本的门德尔随机化 (MR) 框架.
  • 使用了多步骤的优先级策略,并与大量的转录基因数据交叉.

主要成果:

  • 确定了303个显著的细胞特异性基因特征关联,在细胞类型之间存在有限的重叠.
  • 在14种免疫细胞类型中优先考虑了35种高度自信的基因.
  • 发现单细胞和全血eQTL之间的一致性有限,强调了细胞特异性分析的重要性.

结论:

  • 阿尔茨海默病的遗传风险是由免疫细胞状态的多种细胞特异性机制介导的.
关键词:
门德尔的随机化亚托邦性皮肤炎的发生我们的eQTL是eQTL.湿疹和湿疹是一个问题.一个单细胞的单细胞.转录组广泛的关联研究研究.

更多相关视频

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.4K

相关实验视频

Last Updated: Jul 3, 2026

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation
07:11

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

22.3K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.4K
  • 鉴定出与免疫相关的可用药物基因,如IL2RA,具有明显的细胞特异性影响.
  • 这些发现对开发针对性治疗治疗皮炎的治疗干预措施有意义.