相关实验视频
Updated: Mar 15, 2026

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
24.4K
在患有自身免疫性原发性上腺功能衰竭的患者中GDF15
Aleksandra Zdrojowy-Wełna1, Jowita Halupczok-Żyła2, Katarzyna Kolačkov3
1Department of Endocrinology and Internal Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.
International journal of molecular sciences
|March 14, 2026
概括
增长分化因子15 (GDF15) 在原发性上腺功能衰竭 (PAI) 中升高. 在PAI患者中,更高的GDF15水平与疾病持续时间和自身免疫标志物相关,这表明在这种疾病中发挥了作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
- 应激反应生物学 应激反应生物学
背景情况:
- 增长分化因子15 (GDF15) 是一种应激反应蛋白,与体重调节有关.
- 在葡萄糖皮质激素缺乏症期间,GDF15水平上升,这是与原发性上腺功能不足 (PAI) 相关的疾病.
- 在PAI患者中影响GDF15水平的因素需要进一步调查.
研究的目的:
- 为了比较自身免疫PAI患者和健康对照者之间的血清GDF15水平.
- 调查GDF15水平与PAI患者的临床参数之间的关联.
主要方法:
- 血清GDF15水平测定在37名自身免疫PAI患者和47名健康对照患者中.
- 在所有参与者中评估了人类计量,荷尔蒙和生化参数.
- 进行了统计分析,以比较群体并确定相关性.
主要成果:
- 患有PAI的患者的GDF15水平明显高于对照组 (1276.8 ± 952.1 与682.8 ± 270.2 pg/mL,p < 0.001).
- 在两组中,GDF15水平与年龄正相关.
- 在PAI患者中,GDF15与疾病持续时间,自身免疫性甲状腺疾病持续时间,淋巴激素水平,腰部至部比率和身体脂肪百分比有积极的相关性.
- 在PAI患者中,GDF15与脱水氨二硫酸 (DHEAS) 和性激素水平呈负相关性.
结论:
- 与健康个体相比,患有原发性上腺功能不全的患者的循环GDF15水平较高.
- 在PAI中GDF15水平与疾病持续时间和自身免疫过程标志物有关.
- 这些发现表明GDF15在PAI的病理生理学或临床表现方面可能发挥作用.
相关概念视频
Adrenal Gland Disorders
3.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.7K
Hormones of the Adrenal Glands
6.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
6.3K
Autoimmune Disorders
2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
Insulin: Dosing Regimen and Adverse Effects
1.0K
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
1.0K
Anatomy of the Adrenal Glands
5.6K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
5.6K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
595
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
595

