酸循环基因和营养遗传学
Anna Vesnina1, Oksana Kozlova2, Svetlana Ivanova3,4
1DNA Sequencing and Genomics Laboratory, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650043, Russia.
International journal of molecular sciences
|March 14, 2026
概括
酸循环 (TCA循环) 的破坏与慢性疾病有关. 营养素和饮食变化显示出通过影响TCA循环遗传学和表观遗传学来预防和治疗这些疾病的潜力.
科学领域:
- 生物化学 生物化学
- 遗传学 遗传学 是一个
- 营养科学 营养科学
背景情况:
- 酸循环 (TCA循环) 的中断与糖尿病,肥胖,癌症和心血管疾病等慢性疾病有关.
- TCA循环障碍与瘤,神经退行性和骨质疏松性疾病有关,单核酸多态性作为潜在标记物.
- 生活方式和饮食是线粒体功能障碍的重要危险因素,强调了预防性研究的重要性.
研究的目的:
- 审查45年来关于TCA循环,其遗传学,表观遗传学和营养素的作用的研究.
- 介绍编码TCA循环酶的收集基因及其与疾病的关联.
- 通过表观遗传修饰,探索营养对TCA循环活动的影响.
主要方法:
- 关于PubMed,Elsevier和eLIBRARY.RU (英语和俄语) 出版物的综合文献评论.
- 收集和呈现编码TCA循环酶的基因.
- 对影响TCA周期的基因表达变化,突变和表观遗传修饰现有证据的分析.
主要成果:
- 特定的基因表达变化 (例如,在ACO2) 和突变 (例如,在IDH1,IDH2,DLST) 与神经退行性疾病和癌症有关.
- 营养通过表观遗传修饰影响TCA循环活动.
- 一些营养素 (尼亚,α-利波酸,白醇等) 在基因层面影响TCA循环调节.
结论:
- TCA循环是理解和管理慢性疾病的关键目标.
- 营养素和生物活性化合物通过调节TCA循环遗传学和表观遗传学,具有治疗干预的潜力.
- 对植物代谢物,维生素和补充剂的进一步研究可以加强预防性和治疗性饮食策略.
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