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Updated: Mar 15, 2026

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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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由食物和环境基因毒素引发的细胞衰老
Bernd Kaina1, Maja T Tomicic1, Markus Christmann1
1Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.
International journal of molecular sciences
|March 14, 2026
概括
来自食物和环境的外部基因毒素会触发细胞衰老 (CSEN),这是一个与衰老和器官衰竭相关的过程. 减少对这些毒素的暴露和使用老年疗法可以抵消衰老.
科学领域:
- 细胞和分子生物学 细胞和分子生物学
- 毒理学 毒理学 毒理学
- 老年学是一门学科.
背景情况:
- 细胞衰老 (CSEN) 是由各种压力因素引发的复杂过程,包括基因毒素对DNA造成的损伤.
- 来自环境和饮食来源的外源性基因毒素越来越多地被认为是CSEN的诱导剂.
- 通过与衰老相关的分泌表型 (SASP),CSEN与衰老,器官衰竭和与年龄有关的疾病有关.
研究的目的:
- 通过食物和环境暴露的外源性基因毒性侮辱来审查细胞衰老的诱导.
- 突出这些外部因素在CSEN诱导过程中所涉及的分子途径.
- 讨论CSEN对衰老和器官功能的影响.
主要方法:
- 对研究外源性基因毒素CSEN诱导的研究的文献综述.
- 对烟草,食品,饮料和生活方式产品中存在的基因毒素数据的分析.
- 检查分子机制,包括DNA损伤反应 (DDR) 途径.
主要成果:
- 烟草烟雾,环境,食品和生活方式产品中的基因毒素/致癌物诱导CSEN.
- 确定的基因毒素包括N-酸盐化合物,PAH,HAC,烯胺,重金属和真菌毒素.
- 基因毒素的CSEN诱导涉及DDR通路 (ATM/ATR-CHK2/CHK1-p53-p21,p53-独立的p16/p14) 和其他信号级联.
结论:
- 外源性基因毒素显著促进CSEN诱导,可能加剧衰老和器官衰竭.
- 饮食和环境基因毒素诱导的CSEN的作用可能被低估了.
- 减少基因毒素暴露和使用老年疗法是减轻CSEN和衰老的建议策略.
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