人类精子中的与年龄相关的代谢变化
Mohd Amin Beg1, Md Shawkat Khan1,2, Ishfaq Ahmad Sheikh1
1King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
International journal of molecular sciences
|March 14, 2026
概括
由于精子代谢的变化,男性的生育能力随着年龄的增长而下降. 这项研究确定了因衰老而改变的关键精子代谢物,为保护生殖健康提供了潜在的生物标志物.
科学领域:
- 生殖生物学 生殖生物学
- 代谢学 代谢学 代谢学
- 衰老研究研究 衰老研究
背景情况:
- 与衰老相关的男性生育能力下降是一个越来越令人担忧的问题.
- 这种衰退背后的特定功能性基因组和代谢机制尚未得到充分理解.
- 精子生物随着年龄的增长经历了显著的代谢变化,影响了它们的功能.
研究的目的:
- 为了研究健康肥沃男性的精子代谢中的与年龄相关的变化.
- 为了确定与衰老和精子功能相关的潜在生物标志物.
- 了解衰老对精子代谢物恒温 (代谢恒温) 的影响.
主要方法:
- 精子样本从三个年龄组的健康肥沃的阿拉伯男性 (年轻人,晚年成人,老年人) 收集.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 进行了代谢分析.
- 使用MetaboAnalyst-Pro进行了统计和功能分析,包括主要组件分析 (PCA) 和部分最小平方差异分析 (PLS-DA).
主要成果:
- 总共有380个代谢物被确定,其中164个显示出与年龄相关的显著差异 (p <0.05).
- 在年轻成人和高级年龄组之间观察到不同的代谢概况.
- 确定了关键代谢物,如L-homocysteine (在晚年无法检测到) 和甲基甲基甲基甲基甲基CoA (在晚年丰富). 发现了137种潜在的衰老精子生物标志物.
结论:
- 年龄的增长会破坏精子代谢,影响精子的完整性和受精能力.
- 已识别的生物标志物参与精子的关键功能,如运动性,能量代谢和氧化应激调节.
- 这些生物标志物代表了旨在保护精子健康和减轻与年龄相关的生育能力下降的干预措施的有希望的目标.
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