黑素作为发育编程中的氧化调节剂:对心血管-,脏-代谢风险的影响
Chien-Ning Hsu1,2,3, You-Lin Tain4,5,6
1Department of Pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan.
International journal of molecular sciences
|March 14, 2026
概括
通过对抗氧化应激,孕产妇补充黑激素有望防止胎儿对心血管,脏和代谢疾病的编程. 需要进一步的研究来确定最佳剂量和对后代的长期安全性.
科学领域:
- 生殖生物学和发育毒理学.
- 内分泌学和代谢研究.
- 产周医学 产周医学
背景情况:
- 黑素对于健康的怀孕和胎儿发育至关重要,表现出抗氧化,抗炎和时代生物特性.
- 在发育过程中过度的氧化应激会导致胎儿不适应性编程,增加心血管,脏和代谢 (CKM) 疾病的终身风险.
- 目前关于母乳黑激素的保护作用的证据主要来自动物模型,结果各不相同.
研究的目的:
- 审查有关黑激素在缓解CKM疾病代际风险方面的机制和转化证据.
- 探索黑激素作为预防不良胎儿编程的预防策略的潜力.
- 综合有关黑激素对氧化还原稳定,表观遗传通路和肠道微生物群的影响的发现.
主要方法:
- 从实验模型中合成机械学研究.
- 对人类怀孕早期临床研究的审查.
- 对黑素对氧化应激,表观遗传修饰,营养感应和肠道微生物群的影响进行分析.
主要成果:
- 实验研究表明,母亲的黑激素可以通过恢复氧化还原平衡来预防程序化的高血压,功能障碍和代谢问题.
- 黑色素影响表观遗传和营养感应通路,并调节肠道微生物群.
- 初步的临床研究表明,黑激素在怀孕前或子宫内生长限制的怀孕中耐受性良好,改善了胎盘功能和新生儿结局.
结论:
- 孕产妇服用黑激素补充剂通过解决氧化应激和相关途径,显示出预防编程CKM障碍的潜力.
- 临床研究表明,对胎盘功能和新生儿结果有好处,尽管最佳剂量和长期安全性需要进一步研究.
- 黑素成为预防策略的潜在整合性调解者,防止CKM综合征的代际传播.
更多相关视频
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
16.6K
10:00Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
Published on: December 11, 2020
3.1K
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
312
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
312
01:27Redox Reactions
1.3K
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
1.3K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
438
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
438
01:19Management of Insomnia
759
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
759