管道损伤生物标志物是识别长期COVID中早期脏损伤的有用工具
Caio V B Menário1,2, Rodrigo P Silva-Aguiar1,2, Douglas E Teixeira1,2
1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
International journal of molecular sciences
|March 14, 2026
概括
亚临床急性损伤或管状损伤在长期COVID患者中很常见,并且可能会被当前的指导方针遗漏. 与功能测试一起评估管状损伤生物标志物可以改善损伤的早期检测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 亚临床急性损伤 (AKI) 可以发生在没有明显的球功能障碍的情况下.
- 当前脏疾病:改善全球结果 (KDIGO) 标准可能低估了COVID-19相关的脏损伤,因为不包括管状损伤生物标志物 (TDB).
研究的目的:
- 为了评估长期COVID患者的损伤.
- 评估TDBs与质生物标志物,蛋白尿 (UPCr) 和白蛋白尿 (UACr) 一起进行评估.
主要方法:
- 对75名长期COVID患者没有先前慢性脏病的横截面研究.
- 在COVID-19 (MPC) 后6个月,12个月和24个月的阶层化组.
- 估计膜过率 (eGFR),TDBs,UACr和UPCr的评估.
主要成果:
- 几乎一半的患者具有正常的eGFR (>90mL/min/1.73m2).
- 在正常EGFR患者中,29.7%的患者表现出异常的TDB,UACr或UPCr,表明管道损伤.
- 管状损伤生物标志物在6-MPC时更为普遍,而质功能障碍增加了24-MPC.
结论:
- 长期COVID中脏损伤比以前认为的更为常见.
- 在长期COVID中,TDB评估对于早期检测损伤至关重要.
- 目前的KDIGO标准可能无法完全捕捉COVID-19后损伤的范围.
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